Adrenal function links to early postnatal growth and blood pressure at age 6 in children born extremely preterm

被引：15

作者：

Watterberg, Kristi L. ^{[1
]}

Hintz, Susan R. ^{[2
,3
]}

Do, Barbara ^{[4
]}

Vohr, Betty R. ^{[5
]}

Lowe, Jean ^{[1
]}

Newman, Jamie E. ^{[4
]}

Wallace, Dennis ^{[4
,27
]}

Lacy, Conra Backstrom ^{[1
]}

Davis, Elysia Poggi ^{[6
]}

Granger, Douglas A. ^{[7
]}

Shankaran, Seetha ^{[8
]}

Payne, Allison ^{[9
]}

Higgins, Rosemary D. ^{[10
]}

Jobe, Alan H. ^{[11
]}

Caplan, Michael S. ^{[12
]}

Polin, Richard A. ^{[13
]}

Laptook, Abbot R. ^{[14
,15
]}

Hensman, Angelita M. ^{[14
,15
]}

Vieira, Elisa ^{[14
,15
]}

Little, Emilee ^{[14
,15
]}

Johnson, Katharine ^{[14
,15
]}

Alksninis, Barbara ^{[14
,15
]}

Keszler, Mary Lenore ^{[14
,15
]}

Knoll, Andrea M. ^{[14
,15
]}

Leach, Theresa M. ^{[14
,15
]}

McGowan, Elisabeth C. ^{[14
,15
,29
]}

Watson, Victoria E. ^{[14
,15
]}

Walsh, Michele C. ^{[16
]}

Fanaroff, Avroy A. ^{[16
]}

Wilson-Costello, Deanne E. ^{[16
]}

Newman, Nancy S. ^{[16
]}

Siner, Bonnie S. ^{[16
]}

Zadell, Arlene ^{[16
]}

DiFiore, Julie ^{[16
]}

Bhola, Monika ^{[16
]}

Friedman, Harriet G. ^{[16
]}

Yalcinkaya, Gulgun ^{[16
]}

Goldberg, Ronald N. ^{[17
,18
]}

Cotten, C. Michael ^{[17
,18
]}

Gustafson, Kathryn E. ^{[17
,18
]}

Goldstein, Ricki F. ^{[17
,18
]}

Ashley, Patricia ^{[17
,18
]}

Auten, Kathy J. ^{[17
,18
]}

Fisher, Kimberley A. ^{[17
,18
]}

Foy, Katherine A. ^{[17
,18
]}

Freedman, Sharon F. ^{[17
,18
]}

Lohmeyer, Melody B. ^{[17
,18
]}

Malcolm, William F. ^{[17
,18
]}

Wallace, David K. ^{[19
,20
]}

Carlton, David P. ^{[19
,20
]}

机构：

[1] Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA

[2] Stanford Univ, Dept Pediat, Div Neonatal & Dev Med, Palo Alto, CA 94304 USA

[3] Lucile Packard Childrens Hosp, Palo Alto, CA USA

[4] RTI Int, Social Stat & Environm Sci Unit, Res Triangle Pk, NC USA

[5] Brown Univ, Women & Infants Hosp, Dept Pediat, Providence, RI 02908 USA

[6] Univ Denver, Dept Psychol, Denver, CO 80208 USA

[7] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA USA

[8] Wayne State Univ, Dept Pediat, Detroit, MI 48202 USA

[9] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA

[10] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA

[11] Univ Cincinnati, Cincinnati, OH 45221 USA

[12] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA

[13] Columbia Univ, Coll Phys & Surg, Div Neonatol, New York, NY 10027 USA

[14] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA

[15] Women & Infants Hosp Rhode Isl, Providence, RI 02908 USA

[16] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Cleveland, OH 44106 USA

[17] Duke Univ, Sch Med, Univ Hosp, Durham, NC 27706 USA

[18] Duke Reg Hosp, Durham, NC USA

[19] Emory Univ, Grady Mem Hosp, Childrens Healthcare Atlanta, Atlanta, GA 30322 USA

[20] Emory Crawford Long Hosp, Atlanta, GA USA

[21] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA

[22] Indiana Univ, Univ Hosp, Methodist Hosp, Riley Hosp Children, Bloomington, IN 47405 USA

[23] Wishard Hlth Serv, Indianapolis, IN USA

[24] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Houston, TX 77030 USA

[25] Childrens Mem Hermann Hosp, Houston, TX USA

[26] NHLBI, Bldg 10, Bethesda, MD 20892 USA

[27] RTI Int, Res Triangle Pk, NC USA

[28] Stanford Univ, Stanford, CA 94305 USA

[29] Floating Hosp Children, Tufts Med Ctr, Boston, MA USA

[30] Univ Alabama Birmingham Hlth Syst, Birmingham, AL USA

[31] Childrens Hosp Alabama, Birmingham, AL USA

[32] Univ Calif San Diego, Med Ctr, La Jolla, CA 92093 USA

[33] Sharp Mary Birch Hosp Women, San Diego, CA USA

[34] Univ Iowa, Iowa City, IA 52242 USA

[35] Univ Texas Southwestern Med Ctr Dallas, Parkland Hlth & Hosp Syst, Dallas, TX 75390 USA

[36] Childrens Med Ctr Dallas, Dallas, TX USA

[37] Univ Utah, Med Ctr, Intermt Med Ctr, LDS Hosp, Salt Lake City, UT 84112 USA

[38] Primary Childrens Med Ctr, Salt Lake City, UT 84103 USA

[39] Wayne State Univ, Hutzel Womens Hosp, Detroit, MI 48202 USA

[40] Childrens Hosp Michigan, Detroit, MI 48201 USA

来源：

PEDIATRIC RESEARCH | 2019年 / 86卷 / 03期

基金：

美国国家卫生研究院;

关键词：

DEHYDROEPIANDROSTERONE-SULFATE; WEIGHT-GAIN; BIRTH; FETAL; CORTISOL; SALIVARY; DISEASE; STRESS; PAIN;

D O I：

10.1038/s41390-018-0243-1

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BACKGROUND: Low birth weight in term-born individuals correlates with adverse cardiometabolic outcomes; excess glucocorticoid exposure has been linked to these relationships. We hypothesized that cortisol and adrenal androgens would correlate inversely with birthweight and directly with markers of cardiometabolic risk in school-aged children born extremely preterm; further, preterm-born would have increased cortisol and adrenal androgens compared to term-born children. METHODS: Saliva samples were obtained at age 6 from 219 preterm-born children followed since birth and 40 term-born children and analyzed for dehydroepiandrosterone (DHEA) and cortisol. Cortisol was also measured at home (awakening, 30' later, evening). RESULTS: For preterm-born children, cortisol and DHEA correlated inversely with weight and length Z-scores at 36 weeks PMA and positively with systolic BP. DHEA was higher in preterm-born than term-born children (boys p < 0.01; girls p = 0.04). Cortisol was similar between preterm-born and term-born at study visit; however, preterm-born children showed a blunted morning cortisol. In term-born children, DHEA correlated with BMI (p = 0.04), subscapular, and abdominal skinfold thicknesses (both p < 0.01). CONCLUSION: Cortisol and DHEA correlated inversely with early postnatal growth and directly with systolic BP in extremely preterm-born children, suggesting perinatal programming. Blunted morning cortisol may reflect NICU stress, as seen after other adverse childhood experiences (ACEs).

引用

页码：339 / 347

页数：9

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