Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8)

被引：10
|
作者：
Ding, Derong [1 ]
Lichtenwalter, Katerina [1 ]
Pi, Hualiang [1 ]
Mobashery, Shahriar [1 ]
Chang, Mayland [1 ]
机构：
[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
来源：
MEDCHEMCOMM | 2014年 / 5卷 / 09期
关键词：
MODULATORS; EXPRESSION; ROLES; NMR;
D O I：
10.1039/c4md00172a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MMP-8 has been implicated in various diseases. Selective MMP-8 inhibitors are needed to ascertain the role of this enzyme. We synthesized two inhibitors reported previously as selective for MMP-8. Compound 1 selectively inhibited MMP-8 and MMP-13; compound 2 was a potent broad-spectrum inhibitor, notwithstanding that it is used as a selective one.
引用
收藏
页码：1381 / 1383
页数：3
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