Sono-activatable Photosensitizer for Photodynamic Therapy

被引：3
|
作者：
Horiuchi, Hiroaki [1 ,2 ]
Kano, Takayuki [1 ]
Uehara, Hiroki [1 ]
Okutsu, Tetsuo [1 ]
机构：
[1] Gunma Univ, Fac Sci & Technol, Div Mol Sci, Kiryu, Gunma 3768515, Japan
[2] Gunma Univ, Fac Sci & Technol, Int Educ & Res Ctr Silicon Sci, Kiryu, Gunma 3768515, Japan
来源：
CHEMISTRY LETTERS | 2014年 / 43卷 / 09期
基金：
日本科学技术振兴机构;
关键词：
SINGLET OXYGEN; IN-VITRO; TETRAPHENYLPORPHYRIN; ENHANCEMENT; PHOSPHORESCENCE;
D O I：
10.1246/cl.140403
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A carboxy tetraphenylporphyrin derivative formed aggregate by decreasing its pH, and suppressed its fluorescence and sensitization of singlet oxygen. This indicates that ON/OFF switching of the photosensitization can be achieved by aggregation and disaggregation of photosensitizers. To induce disaggregation, ultrasound was applied to the solution of the aggregate of photosensitizers, and disaggregation was confirmed by studying the fluorescence of the photosensitizer and phosphorescence of singlet oxygen sensitized. Thus this system works as a sono-activatable photosensitizer for photodynamic therapy.
引用
收藏
页码：1423 / 1425
页数：3
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