Grafting Drugs to Functionalized Single-wall Carbon Nanotubes as a Potential Method for Drug Delivery

被引：5
|
作者：
Heidarian, M. [1 ]
Khazaei, A. [1 ]
Saien, J. [1 ]
机构：
[1] Bu Ali Sina Univ, Fac Chem, Hamadan 6517838683, Hamadan, Iran
来源：
PHYSICAL CHEMISTRY RESEARCH | 2021年 / 9卷 / 01期
关键词：
Single wall carbon nanotube; Kinetic; Drug release; SWCNT-drug grafting; RELEASE; TRANSPORTERS; STRATEGIES; MATRICES; AGENTS;
D O I：
10.22036/pcr.2020.232018.1775
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The mesalazine and fluvoxamine drugs were grafted to single-walled carbon nanotubes (SWCNTs) aiming at precise drug delivery. First, carboxylic groups in SWCNT were converted to corresponding acyl chlorides. Next, in order to form the amide bonds, acyl chloride-SWCNTs were mixed with chemotherapeutic agents having NH2 and NH functional groups. Then, the covalently grafted drugs to SWCNT were characterized by UV-Vis, IR spectroscopy, and transmission electron microscopy methods. Finally, the prepared organic compounds were used for releasing drugs at pH: 1.3, which is corresponding to clinical aspects of the human body, and were examined for the potential of drug delivery in patients. Accordingly, the in-vitro kinetic as well as the mechanism of the released drugs were investigated.
引用
收藏
页码：57 / 68
页数：12
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