The Morphology of Paca (Cuniculus paca) Testis with High Dose of Letrozole an Aromatase Inhibitor

被引：0

作者：

Simoes, Luciana Senna ^{[1
]}

de Castro Sasahara, Tais Harumi ^{[1
]}

Favaron, Phelipe Oliveira ^{[1
]}

Leal, Leonardo Martins ^{[2
]}

de Oliveira, Fabricio Singaretti ^{[3
]}

Fratini, Paula ^{[1
]}

Berger, Trish ^{[4
]}

Fernandes Machado, Marcia Rita ^{[3
]}

Miglino, Maria Angelica ^{[1
]}

机构：

[1] Univ Sao Paulo FMVZ USP, Sch Vet Med & Anim Sci, Dept Surg, Av Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, SP, Brazil

[2] Uninga Dept Med Vet, Fac Ingn, Rod PR 317,6114 Parque Ind Duzentos, BR-87035510 Maringa, PR, Brazil

[3] Univ State Sao Paulo FCAV UNESP, Dept Anim Morphol & Physiol, Via Acesso Prof Paulo Donato Castellane S-N, BR-14884900 Jaboticabal, SP, Brazil

[4] Univ Calif Davis, Dept Anim Sci, 1 Shields Ave, Davis, CA 95616 USA

来源：

INTERNATIONAL JOURNAL OF MORPHOLOGY | 2020年 / 38卷 / 06期

关键词：

Gonadal; Toxic; Spermatogenesis;

D O I：

暂无

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The study reported the influence of the high and acute dose of Letrozole on the testis morphology in paca (Cuniculus paca), an aromatase inhibitor that reduces the endogenous estrogen, the essential hormone for spennatogenesis. Morphological changes were observed in seminiferous epithelium with germ cells with apoptotic characteristics and presence of vacuoles and nuclei in pycnose.

引用

页码：1525 / 1527

页数：3

共 36 条

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[33] Phase I/II dose-escalation study of PI3K inhibitors pilaralisib or voxtalisib in combination with letrozole in patients with hormone-receptor-positive and HER2-negative metastatic breast cancer refractory to a non-steroidal aromatase inhibitor
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[35] A Phase 1/2 Dose-Escalation Study of SAR245408 (508) or SAR245409 (S09) in Combination with Letrozole (L) in Subjects with Hormone Receptor-Positive and HER2-Negative (HR+/HER2-) Breast Cancer (BC) Refractory to a Nonsteroidal Aromatase Inhibitor (AI)
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[36] High nuclear p27kip1 levels predicts sensitivity to neoadjuvant letrozole in ER plus breast cancer independent of pAKT levels, PIK3CA mutation status and cell cycle effects:: a potential role for p27kip1 in predicting enhanced autophagocytosis in response to aromatase inhibitor therapy.
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