Self-assembly of Cu(II) with amyloid β19-20 peptide: relevant to Alzheimer's disease

被引：6

作者：

Shen, Xiaofang ^{[1
]}

Deng, Xiaorong ^{[1
]}

Pang, Yuehong ^{[1
]}

机构：

[1] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 42期

基金：

中国国家自然科学基金;

关键词：

BETA-PEPTIDE; COPPER COORDINATION; SECONDARY STRUCTURE; NANOSTRUCTURES; NANOTUBES; AGGREGATION; DEMENTIA; PROTEIN; NEURODEGENERATION; FIBRILLIZATION;

D O I：

10.1039/c4ra02758b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amyloid-beta (A beta) peptide A beta 19-20 tends to self-assemble into wellordered tubular structures under physiological conditions, while in the presence of equimolar Cu(II), they assembled into homogeneous microvesicles; a chelator can competitively bind to Cu(II) from the Cu(II)-A beta 19-20 complex, resulting in reforming of the peptide tubular structure.

引用

页码：21840 / 21843

页数：4

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