Anti-inflammatory effect of an ethanolic root extract of Heliopsis longipes in vitro

被引:0
|
作者
Hernandez, Ivones [2 ]
Lemus, Yeny [2 ]
Prieto, Sylvia [2 ]
Molina-Torres, Jorge [3 ]
Garrido, Gabino [1 ,2 ]
机构
[1] Univ Catolica Norte, Fac Ciencias, Dept Quim & Farm, Antofagasta, Chile
[2] Ctr Quim Farmaceut, Farmacol Lab, Havana, Cuba
[3] CINVESTAV IPN, Unidad Irapuato, Dept Biotecnol & Bioquim, Mexico City, DF, Mexico
关键词
Heliopsis longipes; inflammation; tumor necrosis factor alpha; nitric oxide; macrophages; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE; PHORBOL ESTER; IFN-GAMMA; ALKAMIDES; ECHINACEA; MACROPHAGES; RESPONSES; AFFININ; PLANTS;
D O I
暂无
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Heliopsis longipes (A. Gray) Blake (Asteraceae) is a species broadly used in Mexican Traditional Medicine. The present study illustrates the effects of the root ethanolic extract from this species on the production of tumor necrosis factor alpha (TNF alpha) and nitric oxide (NO) by activated RAW264.7 macrophage. The extract showed an inhibitory activity on TNF alpha (IC50 = 223.0 mu g/mL) and NO (IC50 = 136.9 mu g/mL). These results represent a contribution to the elucidation of the mechanism involved in the analgesic and anti-inflammatory effects reported for the H. longipes extract.
引用
收藏
页码:160 / 164
页数:5
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