On-chip fluorescence sensing for fluidics platforms using thin film silicon photodetectors

被引：2
|
作者：
Dighe, Aditi [1 ]
Jokerst, Nan [1 ]
机构：
[1] Duke Univ, Dept Elect & Comp Engn, Durham, NC 27708 USA
来源：
BIOMEDICAL OPTICS EXPRESS | 2020年 / 11卷 / 10期
基金：
美国国家科学基金会;
关键词：
A-CHIP; DEVICES; SENSOR;
D O I：
10.1364/BOE.402246
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The integration of fluorescence sensing directly into the fluidic channel in lab-on-a chip systems using thin film Si detectors enables on-chip multi-target medical diagnostics and biochemical analyses. This paper reports on the experimental demonstration and theoretical analysis of a filter-free thin film fluorescence sensor designed for integration into the channel of a fluidic platform. Static tests of this optical sensor show repeatable detection of 6-Hex fluorophore concentrations from 300 nM to 20 mu M, with an average signal-to-noise ratio of 26 dB-50 dB, which agrees well with the theoretical model. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
引用
收藏
页码：5772 / 5782
页数：11
相关论文
共 50 条
  • [21] THIN-FILM PHOTODETECTORS GROWN EPITAXIALLY ON SILICON
    SUTTER, P
    KAFADER, U
    VONKANEL, H
    SOLAR ENERGY MATERIALS AND SOLAR CELLS, 1994, 31 (04) : 541 - 547
  • [22] On-chip photonic microsystem for optical signal processing based on silicon and silicon nitride platforms
    Li, Yu
    Li, Jiachen
    Yu, Hongchen
    Yu, Hai
    Chen, Hongwei
    Yang, Sigang
    Chen, Minghua
    ADVANCED OPTICAL TECHNOLOGIES, 2018, 7 (1-2) : 81 - 101
  • [23] Limits to On-Chip Power Conversion With Thin Film Inductors
    Herget, Philipp
    Wang, Naigang
    O'Sullivan, Eugene J.
    Webb, Bucknell C.
    Romankiw, Lubomyr T.
    Fontana, Robert
    Decad, Gary
    Gallagher, William J.
    IEEE TRANSACTIONS ON MAGNETICS, 2013, 49 (07) : 4137 - 4143
  • [24] The role of surface passivation in integrated sub-bandgap on-chip silicon photodetectors
    Gherabli, Rivka
    Grajower, Meir
    Shappir, Joseph
    Mazurski, Noa
    Levy, Uriel
    2019 CONFERENCE ON LASERS AND ELECTRO-OPTICS (CLEO), 2019,
  • [25] Sub-terahertz silicon-based on-chip absorption spectroscopy using thin-film model for biological applications
    Seyed Ali Hosseini Farahabadi
    Milad Entezami
    Hesam Abouali
    Hadi Amarloo
    Mahla Poudineh
    Safieddin Safavi-Naeini
    Scientific Reports, 12
  • [26] ON-CHIP BOTTOM-GATE POLYSILICON AND AMORPHOUS-SILICON THIN-FILM TRANSISTORS USING EXCIMER LASER ANNEALING
    SHIMIZU, K
    SUGIURA, O
    MATSUMURA, M
    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS, 1990, 29 (10): : L1775 - L1777
  • [27] Sub-terahertz silicon-based on-chip absorption spectroscopy using thin-film model for biological applications
    Farahabadi, Seyed Ali Hosseini
    Entezami, Milad
    Abouali, Hesam
    Amarloo, Hadi
    Poudineh, Mahla
    Safavi-Naeini, Safieddin
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [28] Silicon on Insulator Photonic Integrated Sensors: On-Chip Sensing and Interrogation
    Pozo, J.
    Westerveld, W.
    Harmsma, P. J.
    Yang, S.
    Bodis, P.
    Nieuwland, R.
    Lagioia, M.
    Lo Cascio, D. M. R.
    Staats, J. -P.
    Schmits, R.
    v.d. Berg, H.
    Tabak, E.
    Green, K.
    Urbach, H. P.
    Cheng, L. K.
    Yousefi, M.
    2011 13TH INTERNATIONAL CONFERENCE ON TRANSPARENT OPTICAL NETWORKS (ICTON), 2011,
  • [29] Silicon photonic integrated circuit for on-chip spectroscopic gas sensing
    Xiong, Chi
    Martin, Yves
    Zhang, Eric J.
    Orcutt, Jason S.
    Glodde, Martin
    Schares, Laurent
    Barwicz, Tymon
    Teng, Chu C.
    Wysocki, Gerard
    Green, William M. J.
    SILICON PHOTONICS XIV, 2019, 10923
  • [30] On-Chip Droplets Sensing using Capacitive Technique
    Abdullah, Mohamad Faizal
    Leow, P. L.
    Razak, M. A. Abd
    Harun, F. K. Che
    JURNAL TEKNOLOGI, 2013, 61 (02):
12345