In vivo visualization of tau deposits in corticobasal syndrome by 18F-THK5351 PET

被引：90

作者：

Kikuchi, Akio ^{[1
]}

Okamura, Nobuyuki ^{[2
]}

Hasegawa, Takafumi ^{[1
]}

Harada, Ryuichi ^{[2
]}

Watanuki, Shoichi ^{[4
]}

Funaki, Yoshihito ^{[5
]}

Hiraoka, Kotaro ^{[4
]}

Baba, Toru ^{[1
]}

Sugeno, Naoto ^{[1
]}

Oshima, Ryuji ^{[1
]}

Yoshida, Shun ^{[1
]}

Kobayashi, Junpei ^{[1
]}

Ezura, Michinori ^{[1
]}

Kobayashi, Michiko ^{[8
]}

Tano, Ohito ^{[9
]}

Mugikura, Shunji ^{[3
]}

Iwata, Ren ^{[5
]}

Ishiki, Aiko ^{[6
]}

Furukawa, Katsutoshi ^{[6
]}

Arai, Hiroyuki ^{[6
]}

Furumoto, Shozo ^{[5
]}

Tashiro, Manabu ^{[4
]}

Yanai, Kazuhiko ^{[2
]}

Kudo, Yukitsuka ^{[7
]}

Takeda, Atsushi ^{[10
]}

Aoki, Masashi ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Neurol, Sendai, Miyagi, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Pharmacol, Sendai, Miyagi, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Diagnost Radiol, Sendai, Miyagi, Japan

[4] Tohoku Univ, Ctr Cyclotron & Radioisotope, Div Cyclotron Nucl Med, Sendai, Miyagi, Japan

[5] Tohoku Univ, Ctr Cyclotron & Radioisotope, Div Radiopharmaceut Chem, Sendai, Miyagi, Japan

[6] Tohoku Univ, Inst Dev Aging & Canc, Dept Geriatr & Resp Med, Sendai, Miyagi, Japan

[7] Tohoku Univ, Inst Dev Aging & Canc, Div Neuroimaging, Sendai, Miyagi, Japan

[8] Tohoku Pharmaceut Univ Hosp, Dept Neurol, Sendai, Miyagi, Japan

[9] Sendai Med Ctr, Dept Neurol, Sendai, Miyagi, Japan

[10] Natl Hosp Org, Sendai Nishitaga Hosp, Dept Neurol, Sendai, Miyagi, Japan

来源：

NEUROLOGY | 2016年 / 87卷 / 22期

关键词：

PROGRESSIVE SUPRANUCLEAR PALSY; BETA-AMYLOID BURDEN; ALZHEIMERS-DISEASE; NEUROFIBRILLARY PATHOLOGY; DEGENERATION; DEMENTIA; TAUOPATHIES; DIAGNOSIS;

D O I：

10.1212/WNL.0000000000003375

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To determine whether F-18-THK5351 PET can be used to visualize tau deposits in brain lesions in live patients with corticobasal syndrome (CBS). Methods: We evaluated the in vitro binding of H-3-THK5351 in postmortem brain tissues from a patient with corticobasal degeneration (CBD). In clinical PET studies, F-18-THK5351 retention in 5 patients with CBS was compared to that in 8 age-matched normal controls and 8 patients with Alzheimer disease (AD). Results: H-3-THK5351 was able to bind to tau deposits in the postmortem brain with CBD. In clinical PET studies, the 5 patients with CBS showed significantly higher F-18-THK5351 retention in the frontal, parietal, and globus pallidus than the 8 age-matched normal controls and patients with AD. Higher F-18-THK5351 retention was observed contralaterally to the side associated with greater cortical dysfunction and parkinsonism. Conclusions: F-18-THK5351 PET demonstrated high tracer signal in sites susceptible to tau deposition in patients with CBS. F-18-THK5351 should be considered as a promising candidate radio-tracer for the in vivo imaging of tau deposits in CBS.

引用

页码：2309 / 2316

页数：8

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