Intracerebroventicular injection of prostaglandin E1 increases γ-aminobutyric acid level in the posterior hypothalamus

被引:3
|
作者
Monda, M [1 ]
Viggiano, A [1 ]
Sullo, A [1 ]
Manzi, G [1 ]
De Luca, V [1 ]
机构
[1] Univ Naples 2, Dept Human Physiol & Integrated Biol Funct F Bott, I-80138 Naples, Italy
关键词
gamma-aminobutyric acid; hyperthermia; posterior hypothalamus; prostaglandin E-1; sympathetic nervous system; rat;
D O I
10.1016/S0306-4565(99)00073-X
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The level of gamma-aminobutyric acid (GABA) in the posterior hypothalamus, the firing rate of the nerves innervating interscapular brown adipose tissue (IBAT), IBAT and colonic temperatures (T-IBAT and T-c) were monitored in urethane-anesthetized male Sprague-Dawley rats. These variables were measured before and after an intracerebroventricular injection of 500 ng prostaglandin E-1 (PGE(1)). The same variables were monitored in other rats with saline injection. The results showed that PGE1 caused an increase in GABA concentration, firing rate, T-IBAT, T-c These findings suggest that GABA-ergic tone in the posterior hypothalamus is important in the control of the sympathetic and thermogenic changes induced by PGE(1). (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:359 / 363
页数:5
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