Antiviral activity of indole derivatives

被引：66
|
作者：
Giampieri, Michele [1 ]
Balbi, Alessandro [1 ]
Mazzei, Mauro [1 ]
La Colla, Paolo [2 ]
Ibba, Cristina [2 ]
Loddo, Roberta [2 ]
机构：
[1] Univ Genoa, Dept Pharmaceut Sci, I-16132 Genoa, Italy
[2] Univ Cagliari, Dept Biomed Sci & Technol, I-09042 Cagliari, Italy
来源：
ANTIVIRAL RESEARCH | 2009年 / 83卷 / 02期
关键词：
RSV; HIV-1; BVDV; YFV; CVB-2; Mannich bases; Indole derivatives; UNSYMMETRICAL METHYLENE DERIVATIVES; MANNICH-BASES; AGENTS;
D O I：
10.1016/j.antiviral.2009.05.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Unsymmetrical methylene derivatives 5 were prepared following a known method, by reaction of the Mannich bases of 2-naphthols 4 with indoles. All synthesized compounds were tested against a wide panel of viruses, since previous work showed that Mannich bases on 7-hydroxycoumarin I and unsymmetrical methylene derivatives 2 were endowed with some antiviral activities. The symmetrical Mannich bases 4 were completely inactive, whereas the unsymmetrical methylene derivatives 5, although possessing a certain degree of toxicity, showed a significant activity against RSV. Some of compounds 5 showed a moderate antiviral activity against HIV-1, BVDV, YFV and CVB-2. The lack of activity of Mannich bases 4 demonstrates the crucial importance for antiviral activity of coumarin moiety present in Mannich bases 1. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：179 / 185
页数：7
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