Antiviral activity of indole derivatives

被引：66
|
作者：
Giampieri, Michele [1 ]
Balbi, Alessandro [1 ]
Mazzei, Mauro [1 ]
La Colla, Paolo [2 ]
Ibba, Cristina [2 ]
Loddo, Roberta [2 ]
机构：
[1] Univ Genoa, Dept Pharmaceut Sci, I-16132 Genoa, Italy
[2] Univ Cagliari, Dept Biomed Sci & Technol, I-09042 Cagliari, Italy
来源：
ANTIVIRAL RESEARCH | 2009年 / 83卷 / 02期
关键词：
RSV; HIV-1; BVDV; YFV; CVB-2; Mannich bases; Indole derivatives; UNSYMMETRICAL METHYLENE DERIVATIVES; MANNICH-BASES; AGENTS;
D O I：
10.1016/j.antiviral.2009.05.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Unsymmetrical methylene derivatives 5 were prepared following a known method, by reaction of the Mannich bases of 2-naphthols 4 with indoles. All synthesized compounds were tested against a wide panel of viruses, since previous work showed that Mannich bases on 7-hydroxycoumarin I and unsymmetrical methylene derivatives 2 were endowed with some antiviral activities. The symmetrical Mannich bases 4 were completely inactive, whereas the unsymmetrical methylene derivatives 5, although possessing a certain degree of toxicity, showed a significant activity against RSV. Some of compounds 5 showed a moderate antiviral activity against HIV-1, BVDV, YFV and CVB-2. The lack of activity of Mannich bases 4 demonstrates the crucial importance for antiviral activity of coumarin moiety present in Mannich bases 1. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：179 / 185
页数：7
相关论文
共 50 条
  • [1] SYNTHESIS OF INDOLE-DERIVATIVES AND THEIR ANTIVIRAL ACTIVITY
    ZHAVRID, SV
    SHASHIKHINA, MN
    GRIBKOVA, NV
    KAZAK, NF
    MIKHALEVA, AI
    TROFIMOV, BA
    VASILIEV, AN
    ZHUNGIETA, GI
    REKHTER, MA
    RADUL, OM
    VLAD, LA
    BUKHANYUK, SM
    ZORIN, LM
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1983, 17 (02): : 153 - 158
  • [2] Design, synthesis and antiviral activity of indole derivatives containing quinoline moiety
    He, Bangcan
    Hu, Yuzhi
    Qin, Yishan
    Zhang, Yufang
    Luo, Xingping
    Wang, Zhenchao
    Xue, Wei
    MOLECULAR DIVERSITY, 2025, 29 (02) : 1091 - 1107
  • [3] Synthesis and antiviral activity of some novel indole-2-carboxylate derivatives
    Xue, Situ
    Ma, Linlin
    Gao, Rongmei
    Li, Yuhuan
    Li, Zhuorong
    ACTA PHARMACEUTICA SINICA B, 2014, 4 (04) : 313 - 321
  • [4] ANTIVIRAL ACTIVITY OF GLYOXALS AND DERIVATIVES
    ANDERSON, EL
    JENSEN, EM
    FORCE, EE
    RIVARD, DE
    EMAS, M
    MATZ, RS
    CASEY, JE
    JOURNAL OF MEDICINAL CHEMISTRY, 1963, 6 (06) : 787 - &
  • [5] The antiviral activity of polysaccharides and their derivatives
    Chen, Ling
    Huang, Gangliang
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 115 : 77 - 82
  • [6] Antimicrobial and antiviral screening of novel indole carboxamide and propanamide derivatives
    Oelgen, SiIreyya
    Altanlar, Nurten
    Karatayli, Ersin
    Bozdayi, Mithat
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2008, 63 (3-4): : 189 - 195
  • [7] EMBRYOTOXIC ACTIVITY OF INDOLE-DERIVATIVES
    LANDAU, MA
    BUZNIKOV, GA
    KABANKIN, AS
    KOLBANOV, VM
    SUVOROV, NN
    TEPLITS, NA
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1977, 11 (01): : 57 - 60
  • [8] Synthesis and Antifungal Activity of Indole Derivatives
    Shaojun Zheng
    Qiaoju Jiang
    Gildas Ngoye Massande
    Wenbin Wu
    Chuansong Lin
    Yue Fang
    Yi Tan
    Rui Zhu
    Chemistry of Natural Compounds, 2023, 59 : 111 - 118
  • [9] INDOLE-DERIVATIVES WITH ANTIMYCOBACTERIAL ACTIVITY
    MAHBOOBI, S
    GROTHUS, G
    MEINDL, W
    ARCHIV DER PHARMAZIE, 1994, 327 (02) : 105 - 114
  • [10] Synthesis and Antifungal Activity of Indole Derivatives
    Zheng, Shaojun
    Jiang, Qiaoju
    Massande, Gildas Ngoye
    Wu, Wenbin
    Lin, Chuansong
    Fang, Yue
    Tan, Yi
    Zhu, Rui
    CHEMISTRY OF NATURAL COMPOUNDS, 2023, 59 (01) : 111 - 118
12345