More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases

被引：98
|
作者：
Buonafine, Mathieu [1 ]
Martinez-Martinez, Ernesto [1 ]
Jaisser, Frederic [1 ,2 ]
机构：
[1] Paris Descartes Univ, Pierre & Marie Curie Univ, Ctr Rech Cordeliers, INSERM,UMRS 1138, Paris, France
[2] F CRIN, INI CRCT, INSERM, Clin Invest Ctr 1433, Nancy, France
来源：
CLINICAL SCIENCE | 2018年 / 132卷 / 09期
关键词：
GELATINASE-ASSOCIATED LIPOCALIN; FACTOR-KAPPA-B; ISCHEMIA-REPERFUSION INJURY; ACUTE KIDNEY INJURY; MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; HEART-FAILURE; PROMOTES; IRON-DEFICIENCY; EXPRESSION;
D O I：
10.1042/CS20171592
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Neutrophil gelatinase-associated lipocalin (NGAL) is a small circulating protein that is highly modulated in a wide variety of pathological situations, making it a useful biomarker of various disease states. It is one of the best markers of acute kidney injury, as it is rapidly released after tubular damage. However, a growing body of evidence highlights an important role for NGAL beyond that of a biomarker of renal dysfunction. Indeed, numerous studies have demonstrated a role for NGAL in both cardiovascular and renal diseases. In the present review, we summarize current knowledge concerning the involvement of NGAL in cardiovascular and renal diseases and discuss the various mechanisms underlying its pathological implications.
引用
收藏
页码：909 / 923
页数：15
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