A convenient palladium-catalyzed carbonylative synthesis of quinazolines from 2-aminobenzylamine and aryl bromides

被引：31
|
作者：
Chen, Jianbin [1 ]
Natte, Kishore [1 ]
Neumann, Helfried [1 ]
Wu, Xiao-Feng [1 ]
机构：
[1] Univ Rostock, Leibniz Inst Katalyse, D-18059 Rostock, Germany
来源：
RSC ADVANCES | 2014年 / 4卷 / 99期
关键词：
STOICHIOMETRIC CARBON-MONOXIDE; ONE-POT SYNTHESIS; O-PHENYL OXIMES; AEROBIC OXIDATION; CASCADE SYNTHESIS; DOMINO REACTIONS; DERIVATIVES; HETEROCYCLES; NUCLEOPHILES; INHIBITORS;
D O I：
10.1039/c4ra11303a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and practical strategy towards quinazoline scaffolds synthesis has been achieved. Through palladium-catalyzed carbonylative coupling of 2-aminobenzylamine with aryl bromides, the desired quinazolines were produced in moderate to good yields for the first time. The reactions followed an aminocarbonylation-condensation-oxidation sequence in a one-pot one-step manner. Preliminary investigation showed DMSO serves both as solvent and oxidant in this procedure.
引用
收藏
页码：56502 / 56505
页数：4
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