Force Measurement Tools to Explore Cadherin Mechanotransduction

被引：11
|
作者：
Stapleton, Sarah C. [1 ]
Chopra, Anant [2 ,3 ]
Chen, Christopher S. [1 ,2 ,3 ]
机构：
[1] Univ Penn, Dept Chem & Biomol Engn, Philadelphia, PA 19104 USA
[2] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[3] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA
来源：
CELL COMMUNICATION AND ADHESION | 2014年 / 21卷 / 03期
关键词：
cadherins; adherens junctions; mechanotransduction; cell adhesions; traction force microscopy; force transduction; ADHERENS JUNCTION COMPONENTS; CELL-ADHESION MOLECULES; ALPHA-CATENIN; IN-VITRO; MECHANICAL TENSION; ACTIN CYTOSKELETON; VINCULIN COOPERATE; LUMEN FORMATION; MATRIX; MORPHOGENESIS;
D O I：
10.3109/15419061.2014.905929
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell-cell adhesions serve to mechanically couple cells, allowing for long-range transmission of forces across cells in development, disease, and homeostasis. Recent work has shown that such contacts also play a role in transducing mechanical cues into a wide variety of cellular behaviors important to tissue function. As such, understanding the mechanical regulation of cells through their adhesion molecules has become a point of intense focus. This review will highlight the existing and emerging technologies and models that allow for exploration of cadherin-based adhesions as sites of mechanotransduction.
引用
收藏
页码：193 / 205
页数：13
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