Pd(II)-Catalyzed arylation of unactivated methylene C(sp3)-H bonds with aryl halides using a removable auxiliary

被引：80
|
作者：
Zhang, Qi [1 ]
Yin, Xue-Song [1 ]
Zhao, Sheng [1 ]
Fang, Sheng-Long [1 ]
Shi, Bing-Feng [1 ,2 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 61期
基金：
美国国家科学基金会;
关键词：
C-H BONDS; CATALYZED DIRECT ARYLATION; CARBON-HYDROGEN BONDS; COUPLING REACTIONS; DIRECTING GROUP; BETA-LACTAMS; PALLADIUM; FUNCTIONALIZATION; ACTIVATION; ALKYLATION;
D O I：
10.1039/c4cc03615h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Pd(II)-catalyzed arylation of methylene C(sp(3))-H bonds in aliphatic amides directed by our newly developed PIP directing group with aryl iodides/bromides has been achieved. Arylation occurs efficiently with a broad range of aryl halides and amides.
引用
收藏
页码：8353 / 8355
页数：3
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