Inhibition of low density lipoprotein oxidation by tetrahydrofurofuran lignans from Forsythia suspensa and Magnolia coco

被引:55
|
作者
Chen, CC
Chen, HY
Shiao, MS
Lin, YL
Kuo, YH
Ou, JC
机构
[1] Natl Res Inst Chinese Med, Taipei 112, Taiwan
[2] Natl Yang Ming Univ, Sch Med, Inst Tradit Med, Taipei 112, Taiwan
[3] Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan
[4] Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan
关键词
Forsythia suspense (Thunb.) Vahl; Oleaceae; Magnolia coco (Lour.) DC; Magnoliaceae; antioxidants; pinoresinol; phillygenin; syringaresinol;
D O I
10.1055/s-1999-14093
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Based on the inhibition of Cu2+-induced LDL oxidation as marker, the major antioxidants in the fruits Of Forsythia suspense and the stems of Magnolia coco were identified. Of these bioactive tetrahydrofurofuran lignans, pinoresinol, phillygenin, and syringaresinol were more potent than probucol. Sesamin and fargesin, which do not contain phenol groups, were found much less active.
引用
收藏
页码:709 / 711
页数:3
相关论文
共 50 条
  • [21] The inhibition of low density lipoprotein oxidation by 17-alpha estradiol
    Dittrich, R
    Müller, A
    Hensen, J
    Wildt, L
    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 1999, 107 (01) : 53 - 57
  • [22] Inhibition of oxidation of low density lipoprotein by vitamin E and related compounds
    Gotoh, N
    Noguchi, N
    Tsuchiya, J
    Morita, K
    Sakai, H
    Shimasaki, H
    Niki, E
    FREE RADICAL RESEARCH, 1996, 24 (02) : 123 - 134
  • [23] INHIBITION OF LOW-DENSITY-LIPOPROTEIN OXIDATION BY NITRIC-OXIDE
    HOGG, N
    PARTHASARTHY, S
    KALYANARAMAN, B
    FREE RADICAL BIOLOGY AND MEDICINE, 1993, 15 (05) : 495 - 495
  • [24] In vitro inhibition of low-density lipoprotein oxidation by a gemfibrozil metabolite
    Kawamura, M
    Hase, K
    Miyazaki, S
    CLINICAL CHEMISTRY, 1996, 42 (04) : 644 - 645
  • [25] Evidence for a paraoxonase-independent inhibition of low-density lipoprotein oxidation by high-density lipoprotein
    Graham, A
    Hassall, DG
    Rafique, S
    Owen, JS
    ATHEROSCLEROSIS, 1997, 135 (02) : 193 - 204
  • [26] Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds
    Kwon, Hyun Sook
    Kim, Min-Jung
    Jeong, Hyung Jae
    Yang, Min Suk
    Park, Ki Hun
    Jeong, Tae-Sook
    Lee, Woo Song
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (01) : 194 - 198
  • [27] Cytoprotective Effect of Lignans from Forsythia suspensa against Peroxynitrite-induced LLC-PK1 Cell Damage
    Piao, Xiang Lan
    Cho, Eun Jung
    Jang, Moon Hee
    Cui, Jian
    PHYTOTHERAPY RESEARCH, 2009, 23 (07) : 938 - 942
  • [28] Inhibition of Human Low-Density Lipoprotein Oxidation In Vitro by Ginger Extracts
    Gunathilake, K. D. Prasanna P.
    Rupasinghe, H. P. Vasantha
    JOURNAL OF MEDICINAL FOOD, 2014, 17 (04) : 424 - 431
  • [29] DIFFERENTIAL INHIBITION OF HUMAN LOW-DENSITY LIPOPROTEIN (LDL) OXIDATION BY THYRONINES
    HANNA, AN
    NEWMAN, HAI
    ARTERIOSCLEROSIS, 1989, 9 (05): : A737 - A737
  • [30] Inhibition of low density lipoprotein oxidation by myrigalone B, a naturally occurring flavonoid
    Mathiesen, L
    Malterud, KE
    Nenseter, MS
    Sund, RB
    PHARMACOLOGY & TOXICOLOGY, 1996, 78 (03): : 143 - 146