Immunotoxic effect of arsenic trioxide on Caenorhabditis elegans

被引：0
|
作者：
Yu, Yan [1 ,2 ]
Zhao, Miao [2 ]
Yu, Lili [2 ]
Pan, Xiaohong [2 ]
Wu, Lingling [2 ]
机构：
[1] Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Peoples R China
[2] Huainan Normal Univ, Dept Life Sci, Huainan, Peoples R China
来源：
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2016年 / 98卷 / 02期
关键词：
immunotoxicity; arsenic; Caenorhabditis elegans; Pseudomonas aeruginosa; fast-killing assay; ASSOCIATION; EXPRESSION; TOXICITY;
D O I：
10.1080/02772248.2015.1113286
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
A Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model was utilized to assess immunotoxic effects of arsenic trioxide (As2O3). After 2h of As2O3 exposure, 500 mu mol L-1 and 1mmol L-1 As2O3 treatment significantly decreased median survivals of C. elegans (10h after L4/adult molt). However, 2 h of As2O3 exposure caused no significant changes in the survivals rates of C. elegans (2h after L4/adult molt). Notably, a significant dose-related immunoenhancement was observed in C. elegans (2h after L4/adult molt) after 12h of arsenite exposure.
引用
收藏
页码：260 / 265
页数：6
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