Regiospecific Synthesis of N2-Aryl 1,2,3-Triazoles from 2,5-Disubstituted Tetrazoles via Photochemically Generated Nitrile Imine Intermediates

被引：10

作者：

Stewart, Sam ^{[1
]}

Harris, Robert ^{[1
]}

Jamieson, Craig ^{[2
]}

机构：

[1] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England

[2] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland

来源：

SYNLETT | 2014年 / 25卷 / 17期

关键词：

photochemistry; regioselectivity; tetrazole; triazole; indazole; EFFICIENT SYNTHESIS; TRIAZOLE; CYCLOADDITIONS; FLUOROPHORES;

D O I：

10.1055/s-0034-1379010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of N2-aryl 1,2,3-triazoles from 2,5-disubstituted tetrazoles was achieved under photochemical conditions. This simple and mild one-step reaction provides regiospecific access to 2,4,5-substituted 1,2,3-triazoles via a nitrile imine intermediate. Syntheses of alkyl and heterocylic derivatives were also investigated.

引用

页码：2480 / 2484

页数：5

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