Synthesis, Self-Assembly, and Drug Release Behavior of Star-Shaped Poly(ε-caprolactone)-b-Poly(ethylene oxide) Block Copolymer with Porphyrin Core

被引：4
|
作者：
Zhao Feng [1 ]
Wang Zhi-Ming [2 ]
Huang Ya-Fei [3 ]
Dai Xiao-Hui [2 ,4 ]
Ge Yan-Ru [3 ]
Pan Jian-Ming [2 ]
Yan Yong-Sheng [2 ,4 ]
Lin Sun [5 ]
机构：
[1] Hosp Affiliated Jiangsu Univ, Zhenjiang 212013, Peoples R China
[2] Jiangsu Univ, Sch Chem & Chem Technol, Dept Chem Engn, Zhenjiang 212013, Peoples R China
[3] Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Peoples R China
[4] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[5] CSR Qingdao Sifang Co Ltd, Qingdao 266111, Shandong, Peoples R China
来源：
JOURNAL OF APPLIED POLYMER SCIENCE | 2014年 / 131卷 / 21期
基金：
中国国家自然科学基金;
关键词：
biocompatibility; biodegradable; copolymers; drug delivery systems; morphology; PHOTODYNAMIC THERAPY; NANOPARTICLES; MICELLES; TRIBLOCK; DELIVERY; POLY(L-LACTIDE); FLUORESCENCE; RECOGNITION; BIOHYBRIDS; GLYCOL);
D O I：
10.1002/app.40996
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
A serial of star-shaped poly(e-caprolactone)-b-poly(ethylene oxide) (SPPCL-b-PEO) block copolymers with porphyrin core were successfully synthesized from ring-opening polymerization (ROP) of epsilon-caprolactone (CL) initiated with porphyrin core, followed by coupling reaction with a hydrophilic polymer poly(ethylene oxide) (PEO) shell. The structure of this novel copolymer were synthesized and thoroughly characterized by Nuclear Magnetic Resonance (NMR), Gel Permeation Chromatography (GPC), Fourier Transform Infrared Spectroscopy (FTIR). Notably, the as-prepared porphyrin-cored star-shaped copolymer could self-assembly into different structures determined by transmission electron microscopy (TEM) and dynamic lighting scattering (DLS), which provides the great potential of using this well-defined photodynamic therapy material for drug delivery system. Particularly, the doxorubicin-loaded SPPCL-b-PEO nanosphere exhibits property of pH-induced drug release. (C) 2014 Wiley Periodicals, Inc.
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页数：8
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