Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?

被引：139
|
作者：
O'Neill, LAJ [1 ]
机构：
[1] Trinity Coll Dublin, Dept Biochem, Dublin, Ireland
来源：
TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 06期
关键词：
D O I：
10.1016/S1471-4906(02)02222-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent evidence suggests that there maybe specificities in the signal transduction pathways activated by different Toll-like receptors (TLRs), with different sets of genes being induced by TLR-4 when compared with TLR-2. These differences may be because of different signalling adapters, with MyD88 being used by several TLRs, and the adapter MyD88-adapter-like (Mal) being recruited specifically by TLR-4. The set of genes being induced may be tailored for the subsequent elimination of the pathogen being recognized, as a result of differences in signal transduction pathways activated by TLRs. These findings may ultimately explain how dendritic cells control specific T-cell responses.
引用
收藏
页码：296 / 300
页数：5
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