Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?

被引：139
|
作者：
O'Neill, LAJ [1 ]
机构：
[1] Trinity Coll Dublin, Dept Biochem, Dublin, Ireland
来源：
TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 06期
关键词：
D O I：
10.1016/S1471-4906(02)02222-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent evidence suggests that there maybe specificities in the signal transduction pathways activated by different Toll-like receptors (TLRs), with different sets of genes being induced by TLR-4 when compared with TLR-2. These differences may be because of different signalling adapters, with MyD88 being used by several TLRs, and the adapter MyD88-adapter-like (Mal) being recruited specifically by TLR-4. The set of genes being induced may be tailored for the subsequent elimination of the pathogen being recognized, as a result of differences in signal transduction pathways activated by TLRs. These findings may ultimately explain how dendritic cells control specific T-cell responses.
引用
收藏
页码：296 / 300
页数：5
相关论文
共 50 条
  • [1] Toll-like receptor and innate immunity
    Uematsu, Satoshi
    Akira, Shizuo
    SEIKAGAKU, 2007, 79 (08): : 769 - 776
  • [2] Toll-like receptor signal transduction
    O'Neill, LA
    FEBS JOURNAL, 2005, 272 : 286 - 286
  • [3] Toll-like receptor signal transduction
    Krishnan, Jayalakshmi
    Selvarajoo, Kumar
    Tsuchiya, Masa
    Lee, Gwang
    Choi, Sangdun
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2007, 39 (04): : 421 - 438
  • [4] Toll-like receptor signal transduction
    Jayalakshmi Krishnan
    Kumar Selvarajoo
    Masa Tsuchiya
    Gwang Lee
    Sangdun Choi
    Experimental & Molecular Medicine, 2007, 39 : 421 - 438
  • [5] Toll-like receptor signals and innate immunity
    Matsuguchi, T
    SEIKAGAKU, 2002, 74 (12): : 1463 - 1468
  • [6] The Toll-like receptor family and innate immunity
    Medzhitov, R
    JOURNAL OF LEUKOCYTE BIOLOGY, 2000, : 11 - 11
  • [7] Activation of innate immunity via chondrocyte toll-like receptor signal transduction in cartilage promotes pseudogout and osteoarthritis
    Liu, R
    Firestein, GS
    Terkeltaub, R
    ARTHRITIS AND RHEUMATISM, 2003, 48 (09): : S415 - S415
  • [8] Toll-like receptors and their role in innate immunity
    Singh, BP
    Chauhan, RS
    Singhal, LK
    CURRENT SCIENCE, 2003, 85 (08): : 1156 - 1164
  • [9] Toll-Like Receptors in Innate Immunity: Role of Bacterial Endotoxin and Toll-Like Receptor 4 in Endometrium and Endometriosis
    Khan, Khaleque Newaz
    Kitajima, Michio
    Hiraki, Koichi
    Fujishita, Akira
    Sekine, Ichiro
    Ishimaru, Tadayuki
    Masuzaki, Hideaki
    GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2009, 68 (01) : 40 - 52
  • [10] Regulation of Toll-like receptor signaling in the innate immunity
    An HuaZhang
    Qian Cheng
    Cao XueTao
    SCIENCE CHINA-LIFE SCIENCES, 2010, 53 (01) : 34 - 43
12345