Antihypertensive Effect of Blueberry Leaves on Spontaneously Hypertensive Rats

被引：0

作者：

Matsuura, Yasushi ^{[1
,2
]}

Kaneko, Mao ^{[3
]}

Hirabaru, Hideaki ^{[4
]}

Hidaka, Fumie ^{[4
]}

Sakaida, Hiroshi ^{[4
]}

Kai, Takanori ^{[4
]}

Yukizaki, Chizuko ^{[2
]}

Sakono, Masanobu ^{[2
,3
]}

机构：

[1] Miyazaki Univ, Interdisciplinary Grad Sch Agr & Engn, Miyazaki 8892192, Japan

[2] Miyazaki Prefectural Food R & D Ctr, Sadowara, Miyazaki 8800303, Japan

[3] Miyazaki Univ, Miyazaki 8892192, Japan

[4] Unkai Shuzo Co Ltd, Res Inst, Aya, Miyazaki 8801303, Japan

来源：

JOURNAL OF THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY-NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI | 2013年 / 60卷 / 12期

关键词：

blueberry leaves; proanthocyanidin; lifestyle disease; anti-hypertensive; ANGIOTENSIN-CONVERTING ENZYME; VACCINIUM-ASHEI; BLOOD-PRESSURE; CRUDE DRUGS; PROANTHOCYANIDINS; INHIBITORS;

D O I：

暂无

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

We evaluated the effects of dried blueberry leaves (BL) and its hot-water extract (BLEx) on blood pressure of spontaneously hypertensive rats (SHR). A continuous 3-week administration of BL (3%) and BLEx (1.5%) reduced systolic blood pressure compared to the control group from the 2-week feeding point Additionally, we fractionated BLEx and investigated the compound responsible for the enhanced blood pressure-lowering effect. BLEx were fractionated into 5-fractions using Sephadex LH-20 and Diaion HP20SS chromatography, and assayed for angiotensin-I-converting enzyme (ACE) inhibitory activity in vitro. The fraction composed of proanthocyanidins showed the most potent inhibitory activity (IC50, 0.004 mg/mL) and reduced systolic blood pressure of SHR. These results suggest that BL and BLEx have anti-hypertensive effects and one of the active components has been identified as a proanthocyanidin.

引用

页码：689 / 694

页数：6

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