Isosteres of chiral clofibric acid analogs: Synthesis, resolution, absolute configuration and HPLC detection of the optical purity

被引：0

作者：

Ferorelli, S

Loiodice, F

Tortorella, V

Amoroso, R

Bettoni, G

ConteCamerino, D

DeLuca, A

机构：

[1] DIPARTIMENTO FARMACOCHIM, I-70126 BARI, ITALY

[2] UNIV G DANNUNZIO, IST SCI FARM, I-66100 CHIETI, ITALY

[3] DIPARTIMENTO FARMACOBIOL, I-70126 BARI, ITALY

来源：

FARMACO | 1997年 / 52卷 / 6-7期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Both racemic and enantiomeric forms of some isosteres of chiral clofibric acid analogs have been synthesized. Also, the absolute configuration has been established by chemical cell-elation and the optical purity determined by a simple HPLC procedure. Moreover, these studies show that the isosteric substitution of the ether oxygen atom of alpha-aryloxy-alkanoic acids with sulfur, amino and methylene groups lead to compounds in which both biological activity and stereoselectivity regarding chloride channel are highly reduced.

引用

页码：367 / 374

页数：8

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