Isosteres of chiral clofibric acid analogs: Synthesis, resolution, absolute configuration and HPLC detection of the optical purity

被引：0
|
作者：
Ferorelli, S
Loiodice, F
Tortorella, V
Amoroso, R
Bettoni, G
ConteCamerino, D
DeLuca, A
机构：
[1] DIPARTIMENTO FARMACOCHIM, I-70126 BARI, ITALY
[2] UNIV G DANNUNZIO, IST SCI FARM, I-66100 CHIETI, ITALY
[3] DIPARTIMENTO FARMACOBIOL, I-70126 BARI, ITALY
来源：
FARMACO | 1997年 / 52卷 / 6-7期
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Both racemic and enantiomeric forms of some isosteres of chiral clofibric acid analogs have been synthesized. Also, the absolute configuration has been established by chemical cell-elation and the optical purity determined by a simple HPLC procedure. Moreover, these studies show that the isosteric substitution of the ether oxygen atom of alpha-aryloxy-alkanoic acids with sulfur, amino and methylene groups lead to compounds in which both biological activity and stereoselectivity regarding chloride channel are highly reduced.
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页码：367 / 374
页数：8
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