The synthesis of 14-membered macrocyclic ethers

被引：0

作者：

Clyne, DS ^{[1
]}

Weiler, L ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

TETRAHEDRON | 1999年 / 55卷 / 48期

关键词：

cyclisation; ethers; macrocyclic; thiocarbonyl compounds;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As part of on ongoing study of the chemistry of macrocyclic compounds, 14-membered macrocyclic ethers with a variety of methyl substitution patterns were synthesized. The preparation of these macrocyclic ethers involved either the Baeyer-Villiger ring expansion of a cyclic ketone, or the macrolactonization of a hydroxy acid to give a lactone. The lactone carbonyl was removed either by conversion to an intermediate thionolactone obtained by reaction with Lawesson's reagent and reduction, or by direct reduction using a boron trifluoride etherate mediated sodium borohydride reaction. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：13659 / 13682

页数：24

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