IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons

被引：75
|
作者：
Hashimoto, Takashi [1 ,2 ]
Maekawa, Shohei [3 ]
Miyata, Seiji [1 ]
机构：
[1] Kyoto Inst Technol, Dept Appl Biol, Sakyo Ku, Kyoto 6068585, Japan
[2] Kyoto Prefectural Univ Med, Dept Anat & Neurobiol, Kyoto, Japan
[3] Kobe Univ, Grad Sch Sci, Div Biol, Nada Ku, Kobe, Hyogo 657, Japan
来源：
CELL BIOCHEMISTRY AND FUNCTION | 2009年 / 27卷 / 07期
基金：
日本学术振兴会;
关键词：
cell adhesion molecule; synapse; hippocampus; neuron; brain; NEURITE OUTGROWTH; RAT-BRAIN; PROTEIN; KILON; ASSOCIATION; OBCAM;
D O I：
10.1002/cbf.1600
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IgLON cell adhesion molecules (CAMs) belonging to the immunoglobulin superfamily comprise of LAMP, neurotrimin (Ntm), OBCAM, and Kilon. In the present study, we performed the single and double transfection of IgLON gene constructs into hippocampal neurons ill vitro and evaluated synaptic number. The quantitative analysis showed that the single over-expression of LAMP or OBCAM increased synaptic number, while the over-expression of Kilon reduced synaptic number and Ntm had no effects. The double over-expression of Kilon-Ntm, Kilon-OBCAM, LAMP-Ntm, and Ntm-OBCAM decreased synaptic number and that of Kilon-LAMP and LAMP-OBCAM had no effect. These results suggest that IgLON CAMS participate in regulating synapse formation in hippocampal neurons. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码：496 / 498
页数：3
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