Pilot study of interferon alpha high-dose induction therapy in combination with ribavirin for chronic hepatitis C in HIV-co-infected patients

被引：29
|
作者：
Rockstroh, JK [1 ]
Mudar, M
Lichterfeld, M
Nischalke, HD
Klausen, G
Gölz, J
Dupke, S
Notheis, G
Stein, L
Mauss, S
机构：
[1] Univ Bonn, Dept Med 1, D-5300 Bonn, Germany
[2] Praxiszentrum Kaiserdamm, Berlin, Germany
[3] Private Practice, Berlin, Germany
[4] Univ Munich, Dr Von Haunerschen Kinderspital, D-80337 Munich, Germany
[5] Private Practice, Dusseldorf, Germany
来源：
AIDS | 2002年 / 16卷 / 15期
关键词：
D O I：
10.1097/00002030-200210180-00016
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Twenty-three HIV/hepatitis C virus (HCV)-coinfected patients received dose-escalated IFN-alpha (5 MIU/day) induction therapy for 10 weeks, followed by 36 weeks of thrice-weekly IFN-alpha treatment (5 MIU), both in combination with ribavirin. Sustained HCV clearance was observed in three patients. Nine patients discontinued the study as a result of adverse reactions such as anaemia, pancreatitis and depression. In HIV/HCV-co-infected patients, the therapeutic benefit of high-dose IFN-alpha therefore seems to be limited by its poor tolerability.
引用
收藏
页码：2083 / 2085
页数：3
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