Association of a 5-HT1Dβ Receptor Gene Polymorphism with Obsessive-Compulsive Disorder in Korean Male Subjects

The 5-HT1D beta receptor gene appears to be particularly interesting in the pathophysiology of obsessive-compulsive disorder (OCD). The 5-HT1D beta receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. We performed an association study of the G861C single nucleotide polymorphism (SNP) of the 5-HT1D beta receptor in 167 male Korean OCD subjects and in 107 controls. Individuals with the G allele had an increased chance of having OCD (OR 1.49, 95% CI 1.05-2.10). Our findings suggest an association between the G861C SNP of the 5-HT1D beta receptor and males with OCD. In the future, other tag SNPs that cover the entire 5-HT1D beta gene region as well as additional SNPs that are supposed to have meaningful functions should be investigated in both male and female OCD subjects. Copyright (C) 2009 S. Karger AG, Basel