RGD-Functionalized Fe3O4 nanoparticles for magnetic hyperthermia

被引：50
|
作者：
Arriortua, Oihane K. [1 ]
Insausti, Maite [1 ,2 ]
Lezama, Luis [1 ,2 ]
Gil de Muro, Izaskun [1 ,2 ]
Garaio, Eneko [3 ]
de la Fuente, Jesus Martinez [4 ,5 ]
Fratila, Raluca M. [4 ,5 ]
Morales, Maria P. [6 ]
Costa, Rocio [6 ]
Eceiza, Maite [7 ]
Sagartzazu-Aizpurua, Maialen [7 ]
Aizpurua, Jesus M. [7 ]
机构：
[1] Basque Ctr Mat Applicat &Nanostruct, BC Mat, UPV EHU Sci Pk, Leioa 48940, Spain
[2] Univ Basque Country, Inorgan Chem Dept, Leioa 48940, Spain
[3] Univ Basque Country, Elect & Elect Dept, Leioa 48940, Spain
[4] Univ Zaragoza, Inst Ciencia Mat Aragon, Grp Biofunct Nanoparticles & Surfaces, CSIC, Zaragoza, Spain
[5] GBER BBN, Zaragoza, Spain
[6] ICMM CSIC, Inst Ciencia Mat Madrid, Biomat & Bioinspired Mat Dept, Madrid 28049, Spain
[7] Univ Basque Country, UPV EHU, Jose Mari Korta R&D Ctr, Donostia San Sebastian 20018, Spain
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2018年 / 165卷
关键词：
Magnetite; RGD; EMR; Citotoxicity; Hyperthermia; IRON-OXIDE NANOPARTICLES; AZIDE-ALKYNE CYCLOADDITION; CLICK CHEMISTRY; ABSORPTION RATE; NANOCRYSTALS; DESIGN; COPPER; CARBODIIMIDE; GROWTH; SHAPE;
D O I：
10.1016/j.colsurfb.2018.02.031
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a "click" chemistry approach. The RGD peptide was linked onto the previously coated nanoparticles in order to target alpha(v)beta(3) integrin receptors over-expressed in angiogenic cancer cells. Different coatings have been analyzed to enhance the biocompatibility of magnetic nanoparticles. Monodispersed and homogeneous magnetite nanoparticles have been synthesized by the seed growth method and have been characterized using X-ray diffraction, thermogravimetric analysis, infrared spectroscopy, transmission electron microscopy and magnetic measurements. The magnetic hyperthermia efficiency of the nanoparticles has also been investigated and cytotoxicity assays have been perfomed for functionalized nanoparticles. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：315 / 324
页数：10
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