Regulation of the Hydrolytic Activity of Mg2+-Dependent Phosphatase Models by Intramolecular NH•••O Hydrogen Bonds

被引：19

作者：

Okamura, Taka-aki ^{[1
]}

Furuya, Ryosuke ^{[1
]}

Onitsuka, Kiyotaka ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Macromol Sci, Toyonaka, Osaka 5600043, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 42期

关键词：

METAL-IONS; BINDING; CARBOXYLATE; CATALYSIS; PROTEINS; ENZYMES; CHEMISTRY; LIGANDS; WATER;

D O I：

10.1021/ja509006x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Magnesium-dependent phosphatase models containing intramolecular NH...O hydrogen bonds were synthesized and structurally characterized by X-ray analysis. The Mg-O bond distances varied with the mode of the hydrogen bonds. H-1 NMR spectra in nonpolar solvents revealed that the acidity of the coordinated water molecule was regulated by the hydrogen bonds. Further, stoichiometric hydrolysis of phosphoric ester significantly depended on the hydrogen bonds. Zinc analogues showed similar but smaller dependencies, which suggest the indispensable role of Mg2+ ion in the activation of the enzymes.

引用

页码：14639 / 14641

页数：3

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