Preparation of radioiodinated ritodrine as a potential agent for lung imaging

被引:35
|
作者
Rashed, H. M. [1 ]
Ibrahim, I. T. [1 ]
Motaleb, M. A. [1 ]
Abd El-Bary, A. [2 ]
机构
[1] Atom Energy Author, Labeled Compound Dept, Hot Lab Ctr, Cairo, Egypt
[2] Cairo Univ, Fac Pharm, Dept Pharmaceut, Giza, Egypt
关键词
Ritodrine; I-125; Chloramine-T; Lung imaging; FLOW;
D O I
10.1007/s10967-014-3077-2
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Ritodrine (a beta-2 adrenergic receptor agonist) was successfully labeled with I-125 via direct electrophilic substitution reaction at ambient temperature. I-125-ritodrine was obtained with a maximum labeling yield of 97 +/- A 0.163 % and in vitro stability up to 24 h. Biodistribution studies showed that maximum in vivo uptake of I-125-ritodrine in lungs was 20.4 +/- A 0.22 % injected activity/g tissue at 1 h post-injection, whereas the clearance from mice appeared to proceed mainly via the renal pathway. I-125-ritodrine is not a blood product and so it is more safe than the currently available Tc-99m-MAA, and its lung uptake is higher than that of the recently discovered Tc-99m(CO)(5)I and Tc-99m-DHPM. As a conclusion, radioiodinated ritodrine could be used as a novel radiopharmaceutical for lung perfusion scan safer than the currently available Tc-99m-MAA and more potential than the recently discovered Tc-99m(CO)(5)I and Tc-99m-DHPM.
引用
收藏
页码:1227 / 1233
页数:7
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