Fe(III)/Bentonite as a Heterogeneous Catalyst for the Synthesis of 3,4-dihydropyrimidin-2-(1H)-ones

Fe(III) immobilized over natural bentonite (bent) using the impregnation method. Prepared catalysts were well characterized by XRD, FT-IR and FeSEM. The catalytic activity of three catalysts 10, 20 and 30 % Fe(III)/bent evaluated for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones known as Biginelli reaction. The catalyst 30 % Fe(III)/bent exhibited a high yield of the product towards the synthesis of a variety of dihydropyrimidones (DHPMs). The high yield of dihydropyrimidone (DHPM) was obtained in model reaction in ethanol, acetonitrile, DMF and solvent - free condition. The reusability test indicated that 6 % of yield of product decreased after 5(th) cycle.