Continuous Crystallization of Pharmaceuticals Using a Continuous Oscillatory Baffled Crystallizer

被引：254

作者：

Lawton, Simon ^{[3
]}

Steele, Gerry ^{[3
]}

Shering, Phil ^{[4
]}

Zhao, Lihua ^{[2
]}

Laird, Ian ^{[2
]}

Ni, Xiong-Wei ^{[1
]}

机构：

[1] Heriot Watt Univ, Sch Engn & Phys Sci, Edinburgh EH14 4AS, Midlothian, Scotland

[2] NiTech Solut Ltd, Scottish Enterprise Technol Pk, E Kilbride G75 0QF, Lanark, Scotland

[3] AstraZeneca R&D Charnwood, Proc R&D, Proc Engn, Loughborough LE11 5RH, Leics, England

[4] AstraZeneca Engn, Macclesfield SK10 4TF, Cheshire, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2009年 / 13卷 / 06期

关键词：

SCALE-UP; ATR-FTIR; MONOSODIUM GLUTAMATE; STIRRED TANKS; IN-LINE; FLOW; SUPERSATURATION; LOOP;

D O I：

10.1021/op900237x

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this paper, we report an investigation into the continuous crystallization of a model active pharmaceutical ingredient (API) using a continuous oscillatory baffled crystallizer (COBC). The results show that continuous crystallization offers significant advantages in terms of process, operation and costs, and delivers the isolation of the model API in just over 12 min compared to the 9 h and 40 min in a batch process.

引用

页码：1357 / 1363

页数：7

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