A Highly Active Cobalt Catalyst System for Kumada Biaryl Cross-Coupling

被引：5
|
作者：
Wu, Wenqin [1 ]
Duong, Hung A. [1 ]
机构：
[1] ASTAR, ICES, 8 Biomed Grove,07-01, Singapore 138665, Singapore
来源：
SYNLETT | 2018年 / 29卷 / 09期
关键词：
carbenes; catalysis; cross-coupling; Grignard reaction; halides; ARYL GRIGNARD-REAGENTS; IRON; HALIDES;
D O I：
10.1055/s-0037-1609337
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly active cobalt catalyst system has been developed for the cross-coupling reactions of arylmagnesium reagents and aryl bromides. In the presence of 1 mol% CoCl2, 2 mol% IPr.HCl and 2 mol% (NaOBu)-Bu-t, a wide range of (hetero)biaryls are prepared in 51 -99% yields at room temperature within a short reaction time.
引用
收藏
页码：1199 / 1202
页数：4
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