L-lactate transport into rat heart mitochondria and reconstruction of the L-lactate/pyruvate shuttle

被引：43
|
作者：
Valenti, D
de Bari, L
Atlante, A
Passarella, S
机构：
[1] CNR, Ctr Studio Mitocondri & Metab Energet, I-70126 Bari, Italy
[2] Univ Bari, Dipartmento Biochim & Biol Mol, I-70126 Bari, Italy
[3] Univ Molise, Dipartimento Sci Anim Vegetali & Ambiente, I-86100 Campobasso, Italy
来源：
BIOCHEMICAL JOURNAL | 2002年 / 364卷 / 01期
关键词：
lactate mitochondrial transport; lactate mitochondrial uptake; lactate/pyruvate antiporter; reducing-equivalent transfer system;
D O I：
10.1042/bj3640101
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In vitro reconstruction of the L-lactate/pyruvate shuttle has been performed, which allows NADH oxidation outside rat heart mitochondria. Such a shuttle occurs due to the combined action of the novel mitochondrial L-lactate/pyruvate antiporter, which differs from the monocarboxylate carrier, and the mitochondrial L-lactate dehydrogenase. The rate Of L-lactate/pyruvate antiport proved to regulate the shuttle in vitro.
引用
收藏
页码：101 / 104
页数：4
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