Effect of ageing on levels of zinc in the lymphoid tissues of the rat

被引:0
|
作者
Saadeddin, SM [1 ]
Abulaban, FS [1 ]
机构
[1] KING SAUD UNIV, COLL SCI, DEPT BIOCHEM, RIYADH, SAUDI ARABIA
来源
MEDICAL SCIENCE RESEARCH | 1997年 / 25卷 / 02期
关键词
zinc; ageing; spleen; thymus; lymphoid tissue;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
To evaluate the effect of ageing on levels of zinc in the spleen and thymus as well as in the serum of rats, we studied three groups of the animals - young adult (3 months old), middle-aged (12-months old), and aged rats (24-months old). Each group contained 10-15 animals. Zinc values were determined by atomic absorption spectrophotometry. Advancing age was associated with a significant increase in spleen zinc (from 21.8 +/- 0.8 to 33.8 +/- 1.0 mu g g(-1) tissue, p < 0.001) and a significant decline in thymus zinc (from 22.7 +/- 1.1 to 15.9 +/- 0.7 mu g g(-1) tissue, p < 0.001). Serum zinc also decreased significantly in the middle-aged rats (from 2.4 +/- 0.2 to 1.7 +/- 0.1 mu g mL(-1), p < 0.01). These findings demonstrate that zinc levels in primary lymphoid tissues are affected by ageing and indicate a possible mechanism by which immune functions progressively decline with age.
引用
收藏
页码:113 / 115
页数:3
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