TIS11 Family Proteins and Their Roles in Posttranscriptional Gene Regulation
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作者:
Baou, Maria
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机构:
Kings Coll London, Div Immunol Infect & Inflammatory Dis, London WC2R 2LS, England
Univ Leicester, MRC, Toxicol Unit, Leicester LE1 7RH, Leics, EnglandKings Coll London, Div Immunol Infect & Inflammatory Dis, London WC2R 2LS, England
Baou, Maria
[1
,2
]
Jewell, Andrew
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机构:
Kingston Univ, Fac Hlth & Social Care Sci, London SW17 0RE, England
St George Hosp, Sch Med, London SW17 0RE, EnglandKings Coll London, Div Immunol Infect & Inflammatory Dis, London WC2R 2LS, England
Jewell, Andrew
[3
,4
]
Murphy, John J.
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Kings Coll London, Div Immunol Infect & Inflammatory Dis, London WC2R 2LS, EnglandKings Coll London, Div Immunol Infect & Inflammatory Dis, London WC2R 2LS, England
Murphy, John J.
[1
]
机构:
[1] Kings Coll London, Div Immunol Infect & Inflammatory Dis, London WC2R 2LS, England
[2] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 7RH, Leics, England
[3] Kingston Univ, Fac Hlth & Social Care Sci, London SW17 0RE, England
[4] St George Hosp, Sch Med, London SW17 0RE, England
Posttranscriptional regulation of gene expression of mRNAs containing adenine-uridine rich elements (AREs) in their 3' untranslated regions is mediated by a number of different proteins that interact with these elements to either stabilise or destabilise them. The present review concerns the TPA-inducible sequence 11 (TIS11) protein family, a small family of proteins, that appears to interact with ARE-containing mRNAs and promote their degradation. This family of proteins has been extensively studied in the past decade. Studies have focussed on determining their biochemical functions, identifying their target mRNAs, and determining their roles in cell functions and diseases. Copyright (C) 2009
机构:
Emory Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Atlanta, GA 30322 USAEmory Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Atlanta, GA 30322 USA
Findley, Mary K.
Koval, Michael
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Emory Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Atlanta, GA 30322 USA
Emory Univ, Sch Med, Dept Cell Biol, Atlanta, GA 30322 USAEmory Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Atlanta, GA 30322 USA