Lipase-catalyzed transesterification of methyl 2-substituted 3-hydroxy-4-pentenoates and its synthetic application to the taxol side chain

被引：14

作者：

Mandai, T ^{[1
]}

Oshitari, T ^{[1
]}

Susowake, M ^{[1
]}

机构：

[1] Kurashiki Univ Sci & Arts, Dept Chem & Biosci, Kurashiki, Okayama 7128505, Japan

来源：

SYNLETT | 2002年 / 10期

关键词：

syn and anti-methyl 2-substituted 3-hydroxy-4-pentenoates; lipase-catalyzed kinetic resolution; 1,2-amino alcohols; the taxol side chain;

D O I：

10.1055/s-2002-34247

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syn-and anti-methyl 2-substituted 3-hydroxy-4-pentenoates were efficiently resolved in lipase-catalyzed transesterification. This protocol was successfully applied to the synthesis of the taxol side chain.

引用

页码：1665 / 1668

页数：4

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