Non-Coding RNA Transcription and RNA-Directed DNA Methylation in Arabidopsis

被引:23
|
作者
He, Xin-Jian [1 ]
Ma, Ze-Yang [1 ]
Liu, Zhang-Wei [1 ]
机构
[1] Natl Inst Biol Sci, Beijing 102206, Peoples R China
关键词
Pol IV; Pol V; siRNA; DNA methylation; RdDM; transcriptional gene silencing; POLYMERASE-II; POL IV; CYTOSINE METHYLATION; HISTONE METHYLATION; PROCESSING CENTER; MUTANTS REVEALS; PLANT; SIRNA; HETEROCHROMATIN; THALIANA;
D O I
10.1093/mp/ssu075
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
RNA-directed DNA methylation (RdDM) is responsible for transcriptional silencing of endogenous transposable elements and introduced transgenes. This process requires non-coding RNAs produced by DNA-dependent RNA polymerases IV and V (Pol IV and Pol V). Pol IV-produced non-coding RNAs are precursors of 24-nt small interfering RNAs, whereas Pol V-produced ncRNAs directly act as scaffold RNAs. In this review, we summarize recent advances in the understanding of RdDM. In particular, we focus on the mechanisms underlying the recruitment of Pol IV and Pol V to chromatin and the targeting of RdDM.
引用
收藏
页码:1406 / 1414
页数:9
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