C/EBPα in leukemogenesis: Identity and origin of the leukemia-initiating cell

被引：9
|
作者：
Schuster, Mikke Bruhn [1 ,2 ]
Porse, Bo Torben [1 ,2 ]
机构：
[1] Univ Copenhagen, BRIC, DK-2200 Copenhagen, Denmark
[2] Copenhagen Univ Hosp, Sect Gene Therapy Res, Copenhagen, Denmark
来源：
BIOFACTORS | 2009年 / 35卷 / 03期
基金：
英国医学研究理事会;
关键词：
C/EBP alpha; hematopoiesis; leukemia; cancer stem cell; ACUTE MYELOID-LEUKEMIA; BINDING-PROTEIN-ALPHA; CEBPA MUTATIONS; STEM-CELLS; TRANSCRIPTION FACTORS; GENE-EXPRESSION; IN-VITRO; TRANSFORMATION; PROLIFERATION; PROGENITORS;
D O I：
10.1002/biof.36
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of the transcription factor CCATT/enhancer binding protein alpha (C/EBP alpha) as a lineage instructive determinant in myelopoiesis is widely accepted. Furthermore, early mutational events ultimately leading to acute myeloid leukemia (AML) often involve abrogation of C/EBP alpha expression and/or function. The main focus of this review is the progression from a preclinical state to AML, and which preleukemic cell population(s) might-in general and in particular in patients with CEBPA mutations-be a target for the secondary genetic and epigenetic events leading to this progression. (C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 3, May/June 2009, Pages 227-231. E-mail: bo.porse@bric.dk
引用
收藏
页码：227 / 231
页数：5
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