Inducible cAMP Early Repressor (ICER) and Brain Functions

被引：56
|
作者：
Borlikova, Gilyana [1 ]
Endo, Shogo [1 ]
机构：
[1] Okinawa Inst Sci & Technol, Unit Mol Neurobiol Learning & Memory, Okinawa 9042234, Japan
来源：
MOLECULAR NEUROBIOLOGY | 2009年 / 40卷 / 01期
关键词：
ICER; CRE-mediated gene transcription; CREB; Long-term plasticity; Epileptogenesis; Learning; Memory; cAMP; cAMP-dependent; Immediate early gene; ELEMENT-BINDING PROTEIN; LONG-TERM-MEMORY; AMP EARLY REPRESSOR; MONOPHOSPHATE EARLY REPRESSOR; TYROSINE-HYDROXYLASE GENE; MESSENGER-RNA EXPRESSION; PROGRAMMED CELL-DEATH; RODENT PINEAL-GLAND; NERVE GROWTH-FACTOR; RESPONSE ELEMENT;
D O I：
10.1007/s12035-009-8072-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The inducible cAMP early repressor (ICER) is an endogenous repressor of cAMP-responsive element (CRE)-mediated gene transcription and belongs to the CRE-binding protein (CREB)/CRE modulator (CREM)/activating transcription factor 1 (ATF-1) gene family. ICER plays an important role in regulating the neuroendocrine system and the circadian rhythm. Other aspects of ICER function have recently attracted heightened attention. Being a natural inducible CREB antagonist, and more broadly, an inducible repressor of CRE-mediated gene transcription, ICER regulates long-lasting plastic changes that occur in the brain in response to incoming stimulation. This review will bring together data on ICER and its functions in the brain, with a special emphasis on recent findings highlighting the involvement of ICER in the regulation of long-term plasticity underlying learning and memory.
引用
收藏
页码：73 / 86
页数：14
相关论文
共 50 条
  • [31] Light-induced expression of transcription factor ICER (inducible cAMP early repressor) in rat suprachiasmatic nucleus is phase-restricted
    Stehle, JH
    Pfeffer, M
    Kuhn, R
    Korf, HW
    [J]. NEUROSCIENCE LETTERS, 1996, 217 (2-3) : 169 - 172
  • [32] The CREM-derived inducible cAMP-early repressor, ICER, antagonizes transcription mediated by both cAMP- and AP1-response elements
    Murphy, TJ
    Wang, XF
    [J]. FASEB JOURNAL, 1998, 12 (08): : A1323 - A1323
  • [33] Induction of the inducible cAMP early repressor (ICER) provides protection against cardiac remodeling after beta-adrenergic stimulation in mice
    Seidl, M. D.
    Sternberg, A.
    Grimm, K.
    Fels, B.
    Stuempel, F. T.
    Kojima, N.
    Endo, S.
    Mueller, F. U.
    [J]. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2016, 389 (01) : S5 - S5
  • [34] Calcitonin induces expression of the inducible cAMP early repressor in osteoclasts
    Maobin Yang
    Barbara E. Kream
    [J]. Endocrine, 2008, 33 : 245 - 253
  • [35] Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart
    Yan, Chen
    Miller, Clint L.
    Abe, Jun-ichi
    [J]. CIRCULATION RESEARCH, 2007, 100 (04) : 489 - 501
  • [36] Calcitonin induces expression of the inducible cAMP early repressor in osteoclasts
    Yang, Maobin
    Krearn, Barbara E.
    [J]. ENDOCRINE, 2008, 33 (03) : 245 - 253
  • [37] The expression of inducible cAMP early repressor (ICER) is altered in prostate cancer cells and reverses the transformed phenotype of the LNCaP prostate tumor cell line
    Yehia, G
    Razavi, R
    Memin, E
    Schlotter, F
    Molina, CA
    [J]. CANCER RESEARCH, 2001, 61 (16) : 6055 - 6059
  • [38] Central Nociceptin/Orphanin (N/OFQ) increases inducible cAMP element repressor (ICER) expression in the rat forebrain
    Gottlieb, HB
    Fleming, TM
    Ferguson, A
    Cunningham, JT
    [J]. FASEB JOURNAL, 2006, 20 (04): : A331 - A331
  • [39] Calcitonin induces expression of the inducible cAMP early repressor in osteoclasts.
    Yang, M.
    Kream, B. E.
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 : S197 - S197
  • [40] Microinjection of a selective kappa opioid agonist into the supraoptic nucleus (SON) increases inducible cAMP element repressor (ICER) expression
    Gottlieb, Helmut
    Martinez, Michelle
    Ji, Lisa
    Cunningham, J. T.
    [J]. FASEB JOURNAL, 2008, 22
12345