Inducible cAMP Early Repressor (ICER) and Brain Functions

被引：56
|
作者：
Borlikova, Gilyana [1 ]
Endo, Shogo [1 ]
机构：
[1] Okinawa Inst Sci & Technol, Unit Mol Neurobiol Learning & Memory, Okinawa 9042234, Japan
来源：
MOLECULAR NEUROBIOLOGY | 2009年 / 40卷 / 01期
关键词：
ICER; CRE-mediated gene transcription; CREB; Long-term plasticity; Epileptogenesis; Learning; Memory; cAMP; cAMP-dependent; Immediate early gene; ELEMENT-BINDING PROTEIN; LONG-TERM-MEMORY; AMP EARLY REPRESSOR; MONOPHOSPHATE EARLY REPRESSOR; TYROSINE-HYDROXYLASE GENE; MESSENGER-RNA EXPRESSION; PROGRAMMED CELL-DEATH; RODENT PINEAL-GLAND; NERVE GROWTH-FACTOR; RESPONSE ELEMENT;
D O I：
10.1007/s12035-009-8072-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The inducible cAMP early repressor (ICER) is an endogenous repressor of cAMP-responsive element (CRE)-mediated gene transcription and belongs to the CRE-binding protein (CREB)/CRE modulator (CREM)/activating transcription factor 1 (ATF-1) gene family. ICER plays an important role in regulating the neuroendocrine system and the circadian rhythm. Other aspects of ICER function have recently attracted heightened attention. Being a natural inducible CREB antagonist, and more broadly, an inducible repressor of CRE-mediated gene transcription, ICER regulates long-lasting plastic changes that occur in the brain in response to incoming stimulation. This review will bring together data on ICER and its functions in the brain, with a special emphasis on recent findings highlighting the involvement of ICER in the regulation of long-term plasticity underlying learning and memory.
引用
收藏
页码：73 / 86
页数：14
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