Prognostic role of vascular endothelial growth factor in cervical cancer: a meta-analysis

被引：37
|
作者：
Zhang, Jing [1 ,2 ,3 ]
Liu, Jiaming [1 ,2 ,4 ]
Zhu, Chenjing [1 ,2 ]
He, Jialing [1 ,2 ]
Chen, Jinna [1 ,2 ]
Liang, Yunliu [1 ,2 ]
Yang, Feng [1 ,2 ]
Wu, Xin [1 ,2 ]
Ma, Xuelei [1 ,2 ]
机构：
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Ctr Canc, Chengdu 610041, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu 610041, Peoples R China
[4] Sichuan Univ, West China Hosp, Lab Reconstruct Urol, Dept Urol,Inst Urol, Chengdu 610041, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 15期
关键词：
VEGF; cervical cancer; prognosis; FACTOR-C EXPRESSION; VEGF EXPRESSION; CARCINOMA; SURVIVAL; SERUM; RADIOTHERAPY; METASTASIS; PREDICTORS;
D O I：
10.18632/oncotarget.15044
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The prognostic role of vascular endothelial growth factor (VEGF) in cervical cancer is controversial to date. The aim of this study was to evaluate the prognostic value of VEGF and VEGF-C in patients with cervical cancer. Relevant studies were identified by systematic search of the PubMed and Embase database. The primary data of eligible studies was hazard ratio (HR) with 95% confidence interval (95% CI) of survival outcomes, including overall survival (OS), disease-free survival (DFS) and progression-free survival (PFS). Pooled HR (95% CI) was calculated to evaluate the prognostic role of VEGF and VEGF-C in cervical cancer patients. The methodological qualities of the included studies were assessed using REMARK. Fourteen eligible articles including 1306 patients were included in the meta-analysis. The pooled HRs (95% CIs) of VEGF for OS and DFS/PFS were 2.29 [1.27, 4.14] and 2.77 [1.37, 5.62], respectively. The HR (95% CI) of VEGF-C for OS was 3.94 [2.22, 6.99]. This meta-analysis suggested that high expressions of VEGF and VEGF-C were significantly associated with poor survival outcome in cervical cancer patients.
引用
收藏
页码：24797 / 24803
页数：7
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