Catalyst-free synthesis of alkyl 4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate derivatives on water

被引：12

作者：

Yan, Hao ^{[1
]}

Ma, Ying ^{[1
]}

Sun, Yuanjun ^{[2
]}

Ma, Chao ^{[1
]}

Wang, Yuling ^{[1
]}

Ren, Xiaoyu ^{[1
]}

Huang, Guosheng ^{[1
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Jin Chuan Grp Co Ltd, Jinchang 737104, Peoples R China

来源：

TETRAHEDRON | 2014年 / 70卷 / 17期

关键词：

Catalyst-free; Green chemistry; Heterocycles; Cycloaddition; On water; Pyrido[1,2-a]pyrimidines; CROSS-COUPLING REACTIONS; EFFICIENT; INHIBITORS; COPPER; HETEROCYCLES; POTENT; AMINOPYRIDINES; BENZOXAZOLES; CYCLIZATION; KETANSERIN;

D O I：

10.1016/j.tet.2014.02.084

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An environmentally friendly and effective method to construct 4H-pyrido[1,2-a]pyrimidin-4-one, which are ubiquitous structural units in a number of biologically active compounds has been developed. In this process, the reaction using water as the solvent in absence of catalyst under the mild conditions makes transformations very green, practical, and attractive. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：2761 / 2765

页数：5

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