Stem cells in the canine pituitary gland and in pituitary adenomas

被引:2
|
作者
van Rijn, Sarah J. [1 ]
Tryfonidou, Marianna A. [1 ]
Hanson, Jeanette M. [2 ]
Penning, Louis C. [1 ]
Meij, Bjoern P. [1 ]
机构
[1] Univ Utrecht, Fac Vet Med, Dept Clin Sci Compan Anim, NL-3508 TD Utrecht, Netherlands
[2] Swedish Univ Agr Sci, Small Anim Hosp, Dept Clin Sci, S-75007 Uppsala, Sweden
关键词
canine; dog; pituitary; stem cells; cancer stem cells; hypercortisolism; Cushing; IN-VITRO CHARACTERIZATION; TRANSSPHENOIDAL HYPOPHYSECTOMY; DEPENDENT HYPERADRENOCORTICISM; TRANSCRIPTION FACTORS; STEM/PROGENITOR CELL; T-BOX; DOGS; CANCER; VIVO; ADENOHYPOPHYSIS;
D O I
10.1080/01652176.2013.873961
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Cushing's disease (CD) or pituitary-dependent hypercortisolism is a common endocrinopathy in dogs, with an estimated prevalence of 1 or 2 in 1000 dogs per year. It is caused by an adrenocorticotropic hormone secreting adenoma in the pars distalis or pars intermedia of the pituitary gland. The pituitary gland is a small endocrine gland located in the pituitary fossa. In the postnatal individual, the hypothalamus-pituitary axis plays a central role in maintaining homeostatic functions, like control of metabolism, reproduction, and growth. Stem cells are suggested to play a role in the homeostatic adaptations of the adult pituitary gland, such as the rapid specific cell-type expansion in response to pregnancy or lactation. Several cell populations have been suggested as pituitary stem cells, such as Side Population cells and cells expressing Sox2 or Nestin. These cell populations are discussed in this review. Also, stem and progenitor cells are thought to play a role in pituitary tumorigenesis, such as the development of pituitary adenomas in dogs. There are limited reports on the role of stem cells in pituitary adenomas, especially in dogs. Further studies are needed to identify and characterize this cell population and to develop specific cell targeting therapeutic strategies as a new way of treating canine CD.
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页码:217 / 224
页数:8
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