Interleukin-12: Role of interferon-gamma in IL-12 adverse effects

被引：57
|
作者：
Ryffel, B
机构：
来源：
CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1997年 / 83卷 / 01期
关键词：
D O I：
10.1006/clin.1996.4306
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin 12 (IL-12) activates natural killer and T cells with the secondary synthesis and release of interferon-gamma (IFN-gamma) and therefore enhances a Th1- or cell-mediated immune response, The immunostimulatory property of IL-12 may be used clinically in cancer and viral diseases. Safety studies in rodents and primates demonstrated a rather small therapeutic window with hepato- and splenomegaly, myelodepression, and lung edema, Investigations in mutant mice deficient for the IFN-gamma receptor (IFN-gamma R-/-) revealed that both the biologic and toxic effects are indirect and largely due to IL-la-induced IFN-gamma. The significance of these findings for the safety in man needs to be explored. (C) 1997 Academic Press.
引用
收藏
页码：18 / 20
页数：3
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