Effects of cooking on oral bioaccessibility of PBDEs, MeO-PBDEs, and OH-PBDEs in fish (tilapia) and chicken egg

Human health concerns are rising with polybrominated diphenyl ethers' (PBDEs) analogues, methoxylated and hydroxylated PBDEs (MeO-PBDEs and OH-PBDEs), due to their occurrences in foods and greater potential toxicological effects than PBDEs. While the oral bioaccessibilities (BA%) of PBDEs in foods are available, such information onMeO-PBDEs and OH-PBDEs, and the effects of cooking on themhave not been adequately addressed. The present study was conducted with fish and chicken egg as typical foods to assess the bioaccessibility (BA%) of PBDEs, MeO-PBDEs, and OH-PBDEs using the colon extended physiologically based extraction test and examine the effects of cooking processes (boiling, frying, and steaming) on them. The results showed that thermal degradation or transformation of the target compounds did not occur during boiling and frying of fish. The BA% of individual PBDEs, MeO-PBDEs, and OH-PBDEs were 20-51% for boiled fish, 11-20% for pan-fried fish, 15-77% for steamed egg, and 42-68% for pan-fried egg. Cooking decreased the BA% of all target compounds in fish due to protein denaturation. However, the BA% of OH-PBDEs in pan-fried egg were greater than those in steamed egg. In addition, the substituent groups of CH3O- and OH- did not pose any effects on the BA% of BDE-47 in fish, but OH-group decreased its BA% in egg. These findings suggested thatMeO-PBDEs and OH-PBDEs exhibited the similar oral BA% in fish to PBDEs, but the underlying mechanismfor the effects of cooking on BA% of OH-PBDEs in egg needs to be further investigated. (c) 2020 Published by Elsevier B.V.