Hybrid SPECT/CT and PET/CT Imaging: The Next Step in Noninvasive Cardiac Imaging

被引:40
|
作者
Kaufmann, Philipp A. [1 ,2 ]
Di Carli, Marcelo F. [3 ,4 ,5 ]
机构
[1] Univ Zurich Hosp, Cardiac Imaging Sect, CH-8091 Zurich, Switzerland
[2] Univ Zurich, Zurich Ctr Integrat Human Physiol ZHIP, Zurich, Switzerland
[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Nucl Med & Mol Imaging,Dept Radiol, Boston, MA 02115 USA
[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Noninvas Cardiovasc Imaging Program,Dept Med Card, Boston, MA 02115 USA
[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Noninvas Cardiovasc Imaging Program,Dept Radiol, Boston, MA 02115 USA
基金
瑞士国家科学基金会;
关键词
CORONARY-ARTERY-DISEASE; MULTISLICE COMPUTED-TOMOGRAPHY; MYOCARDIAL-PERFUSION SPECT; CT ANGIOGRAPHY; CLINICAL-EXPERIENCE; DIAGNOSTIC-ACCURACY; PROGNOSTIC VALUE; GATED SPECT; ISCHEMIA; RISK;
D O I
10.1053/j.semnuclmed.2009.03.007
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The past few years have witnessed impressive advances in the field of noninvasive cardiac imaging. For example, computed tomography (CT) coronary angiography has been adopted into daily clinical routine and, at least in some patient populations, is challenging the role of invasive angiography as the anatomic standard of reference. This is because the latter is associated with a nonnegligible periprocedural morbidity and mortality, which suggests confining its use to patients who will benefit from a revascularization procedure. Many factors that are beyond the quantification of anatomic narrowing and therefore cannot be fully appreciated with morphologic assessment will eventually determine whether or not a given lesion produces stress-induced ischemia. Myocardial perfusion imaging with single-photon emission computed tomography (SPECT) is among the most widely used and well-established noninvasive tools for the diagnosis of ischemic coronary disease. It allows assessment of the physiological relevance of coronary lesions and offers a high prognostic predictive value. Although positron emission tomography (PET) may achieve a higher accuracy than SPECT, its use has so far often been limited to large centers. Recent advances in image processing software and the advent of hybrid scanners have paved the way for fusion of image datasets from different modalities. An ideal, noninvasive technique for the diagnosis of coronary artery disease should provide complementary information on coronary anatomy as well as on pathophysiologic lesion severity. SPECT/CT and PET/CT hybrid imaging can provide such unique information, which not only improves diagnostic assessment and risk stratification but may also guide decision making with regard to revascularization in patients with coronary artery disease. Semin Nucl Med 39:341-347 (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:341 / 347
页数:7
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