Surface modification of PLGA microspheres for targeting

被引：1
|
作者：
Lathia, JD [1 ]
El-Sherif, D [1 ]
Dhoot, NO [1 ]
Wheatley, MA [1 ]
机构：
[1] Drexel Univ, Dept Chem Engn, Philadelphia, PA 19104 USA
来源：
PROCEEDINGS OF THE IEEE 28TH ANNUAL NORTHEAST BIOENGINEERING CONFERENCE | 2002年
关键词：
D O I：
10.1109/NEBC.2002.999547
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
RGD peptide was conjugated to hollow microspheres to develop PLGA ultrasound contrast agents that enhance ultrasound imaging. The microcapsules were coated with an RGD peptide that targets integrins specific to angiogenesis, alphavbeta3 and alphavbeta5. The microcapsules were then bound to rat neuroblastoma cells in vitro within 6 hours. The RGD peptide modified microcapsules makes them ideal candidates for targeted therapeutic imaging and drug delivery vehicles.
引用
收藏
页码：225 / 226
页数：2
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